Keywords: skin penetration, skin PAMPA, Raman spectoscopy, Franz cell Internship Duration: 01/01/22 - 30/06/22
Head of the hosting team: Dr. Szilvia Berko Ph.D dr. habil
Website: Click here
Address of the host laboratory: Research group 2 Team Research group for liquid and semi-solid dosage forms Eötvös u. 6. 6720 Szeged Hungary
Supervisor 1: Dr. Szilvia Berko Ph.D dr. habilE-mail: deakne.berko.szilvia@szte.hu Phone: +3662545573
Supervisor 2: Dr. Anita Kovacs Ph.D.E-mail: gasparne.kovacs.anita@szte.huPhone: +3662545573
During the internship students will have the opportunity to examine penetration through the skin using a variety of techniques such as franz cells, skin PAMPA and Raman spectroscopy. The student will learn to apply these techniques and evaluate the results.
There are various methods regarding of the testing of topical dosage forms among the services provided by the research group. The team provides rheological measurements of semisolid and liquid preparations and investigation of mucoadhesive properties. There is a possibility for in vivo testing of the water content of the stratum corneum, the transepidermal water loss, in vitro drug diffusion through synthetic membranes and drug penetration through heat-separeted human epidermis. Charcterization of skin structure and drug penetration with RAMAN spectroscopy is also possible.
1. Kovács A; Kis N; Budai-Szűcs M; Gácsi A; Csányi E; Csóka I Berkó S QbD-Based investigation of dermal semisolid in situ film-forming systems for local anaesthesia DRUG DESIGN DEVELOPMENT AND THERAPY 2020 : 14 pp. 5059-5076. , 18 p. (2020) 2. Zsikó S; Csányi E; Kovács A; Budai-Szűcs M; Gácsi A; Berkó S Novel In vitro investigational methods for modeling skin permeation: skin PAMPA, raman mapping PHARMACEUTICS 12 : 9 Paper: 803 , 10 p. (2020)
