Keywords: respiratory system, lung function, mechanical ventilation, animal model, cardiopulmonary interactions Internship Duration: 01/01/22 - 31/12/22
Head of the hosting team: Ferenc Peták
Website: Click here
Address of the host laboratory: Cardiopulmonary research laboratory Team Department of Medical Physics and Informatics Koranyi fasor 9 6720 Szeged Hungary
Supervisor: Gergely FodorE-mail: fodor.gergely@med.u-szeged.hu Phone: +3662341291
The cardiopulmonary research laboratory performs scientific activities in various fields of cardiopulmonary physiology and pathophysiology by using translational animal models of lung diseases and performing assessments in clinical environment. A research area is focusing on the involvement of the pulmonary hemodynamics and lung vasculature in various respiratory diseases. We clarify the mechanisms responsible for the lung function deteriorations with a particular focus on the cardiopulmonary interactions. Further research focuses on the characterization of the pulmonary consequences of general anesthesia in various animal models and in clinical environment. Improvement of patient monitoring is essential for the optimization of patient management in anesthesia and intensive care settings. Analyses of the expired gases has great importance in respiratory patient monitoring. Thus we analyze the within-breath dynamics of CO2 exhalation by using capnography to gain insights into the ventilation-perfusion matching. Further research focuses on the pulmonary manifestations of type-2 diabetes mellitus (T2DM) that presents major public health concerns. We characterize the changes in airway function and clarify the deteriorations in the viscoelastic properties of the pulmonary parenchyma, which may be a consequence of lung volume loss, interstitial edema, proliferation, and the effect of advanced glycation endproducts and their interaction with receptors.
• Measurement methodologies for the assessment of lung mechanics in animal models and in clinical environment involving spontaneously breathing subjects and anaesthetized mechanically ventilated patients. • Techniques for circulatory and respiratory monitoring. • Various methods for mechanical ventilation in animal models. • Models of airway hyperresponsiveness. • Inhalation of airborne nanoparticles: exposition and measurement methods. • Analyses of expired gases, evaluation of the dynamics of expired CO2 concentration with capnography, oxygraphy.
Südy R, Peták F, Kiss L, Balogh ÁL, Fodor GH, et al.: Obesity and diabetes: similar respiratory mechanical but different gas exchange defects. Am J Physiol Lung Cell Mol Physiol. 320:L368-L376; 2021 Peták F, Balogh ÁL, Hankovszky P, Fodor GH et al.: Dopamine Reverses Lung Function Deterioration After Cardiopulmonary Bypass Without Affecting Gas Exchange. J Cardiothorac Vasc Anesth. S1053-0770(21)00614-5; 2021 Fodor GH, Bayat S, Albu G, Lin N, Baudat A, Danis J, Peták F, Habre W.: Variable Ventilation Is Equally Effective as Conventional Pressure Control Ventilation for Optimizing Lung Function in a Rabbit Model of ARDS. Front Physiol. 10:803; 2019
